Image 1 - The interconversion of pyruvate and lactate and the associated conversion of NADH to NAD+ using the enzyme lactate dehydrogenase (LDH.) (ChemDraw)
Image 2 - Formation of a ternary complex followed by a conformational change. (ChemDraw)
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Image 3 - Gossypol inhibitors mimic the pyruvate/nicotinamide moiety of NADH to minimize the energy of the pfLDH structure. (ChemDraw) |
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Image 4 - APAD+ analogue binds more efficiently to pfLDH than NAD+ leading to greater catalytic efficiencies (ChemDraw) |
